CBD is increasingly referred to as a cure for everything. It’s logical to use it on a daily basis but does that lead to it losing its effect? Do you build up a tolerance to it through daily use?

What is tolerance?

First of all: what is meant by tolerance? Tolerance is the process whereby someone has to increase their dosage or use of a remedy in order to get the same effect as in the beginning. A good example of this is coffee (caffeine). Think back to your first cup of coffee. You probably bounced around the room from the caffeine. Now you drink coffee every day and one cup of coffee no longer makes any difference to you. To experience the same effect as you did with that first cup of coffee, you now need at least five big cups.

In other words: your body has got used to caffeine. This doesn’t mean that you are addicted or dependent. Your body simply reacts less strongly. This can happen with many different kinds of medicines.

The effect of CBD on the endocannabinoid system

Here’s a little reminder for everyone: CBD is a substance derived from hemp fibre. You can’t get high or stoned from CBD. The substance CBD acts on the endocannabinoid system; simply put, this system is the body’s signalling device. It doesn’t repair anything itself but signals the brain to send reinforcements in due course to resolve the problem.

CBD acts on a pair of receptors within the endocannabinoid system: CB1 and CB2. In particular, CBD works by inhibiting the enzyme FAAH (fatty acid amide hydrolase). This enzyme’s task is to decompose Anandamide. Anandamide is the most important neurotransmitter in our body. Among other things, this transmitter affects memory, thought processes and motor control. Because FAAH is inhibited from decomposing the neurotransmitter, Anandamide builds up in our brain which is beneficial to us.

Research shows…

Whereas we thought at first that you could build up a tolerance to CBD, recent research indicates that this is not the case. The exact opposite effect is achieved: if you take CBD daily. It can just be that you need fewer cannabinoids to achieve the desired effect. No more than that.


Anyone who is a bit knowledgeable in the cannabis world, knows that you can indeed build up a tolerance to THC. Veteran users have to inhale much more of this substance than novice users. However, CBD is not the same as THC. THC can make you stoned or high. This is not the case with CBD. When you take in CBD and THC at the same time, CBD can even reduce the psychoactive effects of THC. Naturally, this all depends on the ratio of THC to CBD.

In short: don’t worry at all

To cut a long story short: can you build up tolerance to CBD? No. Research shows that you don’t have to worry about this in the least. Which is quite exceptional. Especially when you look at substances and medicines for which you can definitely build up a tolerance. We should point out in all honesty that more research is needed to confirm this investigation’s conclusion.

Still not convinced? Then switch to a higher CBD percentage

Despite research indicating that tolerance to CBD doesn’t occur, it could be that you are indeed experiencing this. Research into CBD is still in its infancy. So, do you have doubts about the effects of CBD on your body over time? Then take a small break, switch to a higher CBD percentage or increase the number of CBD drops per day. You might well benefit from that. Build up any increase slowly and cautiously, listen to your body.